题 目：肠促胰岛素在糖尿病发病中起到的作用

主讲人：Jens Juul Holst 教授

丹麦皇家科学院院士

丹麦自然科学院院士

时 间：2018年1月18日（周四） 上午10：00- 11：30

地 点：大学城校区图书馆一楼红棉厅

主讲人简介：

Jens Juul Holst 教授1945年8月出生于丹麦哥本哈根，1978年获得哥本哈根大学医学博士学位，1996年开始任哥本哈根大学医学生理学教授，现任哥本哈根大学诺和诺德基金会基础代谢研究中心科学主任、哥本哈根大学生物医学系副主席等，是丹麦皇家科学院院士、丹麦自然科学院院士。担任Regulatory Peptides、Endocrinology、Diabetes、J Clin Endocrinol Metab、J of Diabetes Investigation等杂志编委委员。

Holst教授是glp-1的发现者以及第一个阐明机制的科学家。他的科研工作的重点是研究胰腺和肠道的调节多肽以及它们在消化道和代谢功能上起到的调节作用，尤其是在血糖、食欲控制，肥胖和糖尿病方面。在这些调节多肽中，主要的研究重点是肠促胰岛素的作用。20多年来，Holst教授管理的研究所每年平均发表30-50篇研究论文，被哥本哈根大学4次授予金奖。Holst教授目前已发表约1648篇论文，其中包括约1300篇原创研究文章，专著章节和论文综述，ISI被引次数>65000，H指数达到128（截止2017年11月），是Lab Times统计的1996年至2006年全球被引次数最多的生理学家（存活的）。获2017年哈灵顿医学创新奖（2万美元，美国临床研究协会ASCI颁发)、2015年The Nordic Fernström Prize (100万瑞典克朗，北欧地区医学研究最高奖项之一)等奖项。培养了25名医学研究人员和30名博士生。

科技处、国际交流与合作处

教师发展中心

2018年1月16日

附：英文简历

Curriculum vitae – Jens Juul Holst

Title:Professor Jens Juul Holst, MD, DMSc

Positions: Professor, Department of Biomedical Sciences and Scientific Director, Novo Nordisk Foundation Center for Basic Metabolic Research, The Faculty of Health and Medical Sciences, University of Copenhagen, Denmark

EDUCATION

1978 Doctor of Medical Sciences, University of Copenhagen, Denmark.

1970 Master in Medical Sciences, Graduation from Medical School, University of Copenhagen.

CURRENTPOSITION(S)

2010 –> Scientific Director, Novo Nordisk Foundation Center for Basic Metabolic Research, section for Translational Metabolic Physiology, The Faculty of Health and Medical Sciences, University of Copenhagen.

2007 –> Vice chairman Dept. Biomedical Sciences, University of Copenhagen.

1996 –> Full Professor of Medical Physiology, University of Copenhagen.

1996 –> Member of the Royal Danish Academy of Science and Letters.

1993 –> Member of the Danish Academy for Natural Sciences.

PREVIOUS POSITIONS

1991 – 1996 Research professor by appointment of the Danish Medical Research Council.

1989 – 1996 Professor of physiology, Dept. Medical Physiology, University of Copenhagen.

1978 – 1989 Associate professor, Dept. Medical Physiology, University of Copenhagen.

1977 – 1978 Assistant professor, Dept. Medical Physiology C, University of Copenhagen.

1976 – 1977 Senior research fellow, Dept. Clinical Chemistry, Bispebjerg Hospital, Copenhagen.

1975 – 1976 Research fellow, Dept. Clinical Chemistry, Bispebjerg Hospital.

1972 – 1988 Surgeon at the Emergency Ward, Bispebjerg Hospital.

1971 – 1975 Research assistant, Dept. Surgery A, Bispebjerg Hospital.

1970 – 1972 Training in surgery, Bispebjerg Hospital, Copenhagen.

AWARDS

2017 The Harrington Prize for Innovation in Medicine ($20,000) (The American Society for Clinical Investigation (ASCI))

2015 The Nordic Fernström Prize (SEK 1,000,000) (one of the most prestigious medical prize in the Nordic countries).

2013 The Anders Jahre Senior Medical Prize (NOK 1,000,000) (the largest biomedical award in the Nordic countries).

2013 The Marie and August Krogh Award, (association of National Medical Societies).

2012 The European Medal of the Society for Endocrinology.

2010 The Bagger-Sørensen Award (DKK 500,000).

2009 The KFJ prize of the Faculty of Health Sciences at the University of Copenhagen (DKK 1.5 mio.).

2009 The Knud Lundbæk award and lecture of the Scandinavian Society for the Study of Diabetes.

2005 The “Claude Bernard lecture and award” of the European Association for the Study of Diabetes.

(15,000 Euro) (the most prestigious European award in Diabetology).

2002 The "Paul Langerhans Medal" of the German Diabetes Association.

1992 The Novo Nordisk Award for Medical Research (DKK 125,000).

1990 The Odd Fellow award for medical research (DKK 200,000).

1984 The Anders Jahre Medical Prize to young medical scientists (DKK 125,000).

GRANTS

From 1987 supported by the Danish Biotechnology programme.

Yearly support from the Novo Nordisk Research Foundation since 1992.

Recipient of 5- and 3-year research grants from The Danish Medical Research Council in 1991, 1996, 2001 and 2004, 2006 and 2008.

Awarded research grants by the Juvenile Diabetes Foundation International in 1997 and 1998. 2002, recipient of a 3-year research grant from European Foundation for the Study of Diabetes (EFSD). Additional EFSD grants in 2006 and 2009.

Grant support from Novartis 2005-2008 and Merck (MSD) 2006-2009.

Grant from FØSU (the Ministry of Higher Education and Science) 2008-10.

UNIK (UNiversitetsforskningens InvesteringsKapital) grant 2009.

One of 5 scientific directors of the 100 mio. € grant from the Novo Nordisk Foundation Center for Basic Metabolic Research.

Advanced ERC Grant for the project "Bypass without Surgery" in 2016, a 5-year research grant.

EDITORIAL BOARDS

Regulatory Peptides; Endocrinology; Diabetes; J Clin Endocrinol Metab; J of Diabetes Investigation.

RESEARCH ADMINISTRATION

Head of a laboratory with a scientific production of 30-50 papers/year for the last 20 years.

Supervisor of more than 25 medical fellows and more than 30 PhD students.

His laboratory has been awarded 4 gold medals of the University.

Vice-chairman of the Biotechnology center for Signal Peptides (1995-2002).

Chairman of the research cluster for Endocrinology and Metabolism at the Health Sciences Faculty, University of Copenhagen, (2004->).

Scientific Director, the Novo Nordisk Foundation Center for Basic Metabolic Research (2010-2020).

INSTITUTIONAL RESPONSIBILITIES

1999-> Member of the Curriculum Committee of the Medical School, University of

Copenhagen.

1997 – 2004 Chairman of the board, Dept. Experimental Medicine, University of Copenhagen.

1996 – 2006 Research Committee (2003-6 executive committee) of the Medical Faculty.

1996 –> Member of board, from 1999 Vice chairman Dept. Biomedical Sciences.

1983 – 1991 Chairman of the council for preclinical studies at the Medical Faculty.

1978 – 1991 Member of the board, Dept. Medical Physiology, University of Copenhagen.

COMMISSIONS OF TRUST

Editorial boards: Regulatory Peptides; Endocrinology (leading journal); Diabetes (leading journal), Journal of Clinical Endocrinology and Metabolism (leading journal), Journal of Diabetes Investigation.

Membership on Scientific Advisory Boards (Pharmaceutical companies): GlaxoSmithKline, NovoNordisk, Zealand Pharmaceuticals, AstraZeneca, Sanofi, MSD, Intarcia, Hamni.

Scientific Consultant for Novo Nordisk (1992à). Previously consulting for MSD, GSK, Novartis, Sanofi, MSD.

SCIENTIFIC PUBLICATIONS

Approx. 1,648 publications (currently 1271 in PubMed under the heading “Holst JJ”) including approx. 1300 original research articles, book chapters and review articles

In total >65,000 citations in ISI Web of Science, 56,654 times cited without self-citation

H-index= 128 (November 2017). According to Lab Times, the most cited (living) physiologist globally 1996-2006

The scientific work has been focused on the regulatory peptides of the pancreas and the gut and their importance in the regulation of the functions of the GI-tract and metabolism, with particular focus on blood glucose and appetite regulation, obesity and diabetes. A particular emphasis has been on the role of the incretin hormones of the gut (GLP-1 and GIP).